Hemp, Marijuana & Cannabis
Are hemp and marijuana the same?
No. Hemp is completely different from marijuana in its function, cultivation and application. Marijuana, as it is widely known, is used for medicinal or recreational purposes. Hemp is used in a variety of other applications like dietary supplements, skincare products, clothing and more.
Marijuana contains many chemical compounds that create the different characteristics of the plant. Terpenes provide flavors and aromas, while chlorophyll in the leaves makes the plant green – but the most important chemicals in marijuana are the cannabinoids.
What is the difference between CBD that is extracted from hemp vs. CBD that is extracted from marijuana?
Hemp and marijuana are species of the Cannabis Sativa plant. There is no difference between CBD that is extracted from the two. CBD is CBD whether it comes from hemp or marijuana.
What is the difference between hemp oil and CBD oil?
The primary difference between hemp oil and CBD oil is where the oil itself is derived from the hemp plant. Hemp oil is derived from the seeds of the hemp plant only. CBD oil is derived from the stalk, stems, leaves or flowers of industrial hemp plants.
What does full spectrum mean?
Full spectrum refers to a range of beneficial cannabinoids (such as CBD, CBC, CBG, CBN), terpenes and phytonutrients that occur naturally in the hemp plant. We believe (and research shows) that these compounds work synergistically together to create much better results than using a CBD isolate.
What does whole spectrum health mean?
We believe in the power of the whole hemp plant, not just parts of it. That’s why our conversations are grounded in a new concept we own called whole spectrum health. Whole spectrum is synonymous with full spectrum, and it is necessary in promoting the entourage effect.
What is the endocannabinoid system?
Did you know you have an endocannabinoid system? You sure do! Most people haven’t heard of it, but it’s an incredibly important system in our bodies. Unfortunately, the endocannabinoid system is not widely taught in school. Only about 13% of medical schools include it at all in their curriculum, so there's a huge knowledge gap.
The endocannabinoid system is a complex biological system in the human body. Dr. Raphael Mechoulam is the chemist who identified the endocannabinoid system in the 90’s. He said it’s impossible to list all of the physiological systems and conditions affected by cannabinoids because there are too many, and much is still unknown about how it works and its interactions.
The endocannabinoid system is made up of two different types of receptors - CB1 and CB2. They act as messengers giving different directions for what your body should do.
CB1 receptors are found throughout the body but are mostly present in the brain and spinal cord. They are concentrated in brain regions associated with the behaviors they influence. For example, there are CB1 receptors in the hypothalamus, which is involved with appetite regulation, and the amygdala, which plays a role in memory and emotional processing. CB1 receptors are also found in nerve endings where they act to reduce sensations of pain.
CB2 receptors tend to be found in the peripheral nervous system. They are especially concentrated in immune cells. When CB2 receptors are activated, they work to reduce inflammation. Inflammation is an immune response which is believed to play a role in many diseases and conditions.
Your endocannabinoid system is responsible for maintaining homeostasis. Homeostasis is the process of maintaining a normal balance in the body and its systems, regardless of what is going on in the external environment.
The ECS helps in regulating anxiety, appetite and hunger, depression, digestion, immune function, memory, mood, motor control, pain, pleasure and reward, reproduction and fertility, your sleep/wake cycle, temperature regulation and so much more!
You can activate your endocannabinoid system by going for a run. When we talk about “runner's high,” we call those endorphins, but they’re actually our endogenous endocannabinoids.
One cannabinoid in particular - anandamide – is known as the “bliss” molecule because it makes us feel really good when we go for a run. If your endocannabinoid system is running on fumes, you can fuel it with plant-derived cannabinoids.
We didn't even realize it existed until the 90’s and that it is responsible for so many different, everyday bodily functions.
What are cannabinoids?
Cannabinoids are chemical compounds that give the cannabis plant its medicinal and recreational properties – plus they hold the key to many health benefits. Among the 113 cannabinoids produced, THC and CBD are the most prevalent and the most well-understood. Most strains of marijuana sold today are cultivated with higher levels of THC.
THC is known for its psychoactive properties and is the reason you feel “high” after ingesting marijuana.
CBD is a non-psychoactive cannabinoid and actually works to counteract the high. CBD also has numerous benefits, such as anti-inflammatory and neuroprotective properties.
Whether produced by the body or in a plant, these naturally-occurring compounds all interact with the endocannabinoid system.
How does CBD affect the endocannabinoid system?
Thanks to the endocannabinoid system, the cannabinoids that are found naturally in cannabis, notably CBD and THC, can bind to cannabinoid receptors and modulate physiological functions in the same way as endocannabinoids. These two cannabinoids, however, have very different ways of interacting.
- Just like the endocannabinoid anandamide, THC binds to CB1 receptors in the brain, with the difference that while anandamide has a calming effect on the brain, THC is psychoactive. FAAH enzymes have the ability to degrade anandamide but are not as effective against THC, which is why the "high" lasts longer.
- CBD, in turn, binds both to CB1 receptors in the brain and to CB2 receptors throughout the body, as a result of which it can benefit the whole body, alleviating mental conditions such as anxiety, as well as physical ailments including muscle spasms, pain and swelling.
The indirect effects of CBD on the endocannabinoid system
Besides receptors, CBD interacts with the endocannabinoid system by modifying the activity of its transport of proteins and enzymes, which in turn modify the concentration of anandamide, the body's "default" endocannabinoid.
When describing the endocannabinoid system, there is a tendency to forget that besides receptors and neurotransmitters, regulating enzymes also play a big part in its functioning. In this case, the key enzyme is the above-mentioned FAAH, which degrades anandamide in a process of which CBD is an inhibitor.
Put another way, cannabidiol reduces the action of the enzyme responsible for degrading anandamide, which leads to a higher concentration of the endocannabinoid in the system - and since anandamide has a calming effect on the brain by blocking the FAAH enzyme, CBD can be of help in treating anxiety disorders.
What is the entourage effect and why is it important?
Cannabinoids, terpenes and other chemical compounds found in cannabis achieve limited success when working in isolation or as individual components. Research suggests that when these individual components of the cannabis plant support one another, therapeutic benefits are magnified. Together, they produce an effect that is greater than the sum of their parts. This phenomenon is known as the “entourage effect.” The entourage effect supports the idea that whole plant medicine is superior to pure extracts.
Will CBD oil make me high?
No. While there are at least 113 known cannabinoids produced by the hemp plant, cannabis is identified by its two active ingredients: THC and CBD. THC is the only molecule in the cannabis family with a psychoactive component. It’s the only one that will get you “high.” CBD, even at extremely high doses, will not make you feel “high.”
Products & Quality
Are your products legal?
On December 20, 2018, President Donald J. Trump signed into law the 2018 Agricultural Improvement Act, otherwise known as the 2018 Farm Bill. This act contained language that completely legalized industrial hemp and ended nearly 80 years of prohibition on the hemp plant. Hemp is now completely exempt from the definition of the Controlled Substances Act.
Furthermore, the 2018 Farm Bill clarified the definition of hemp — often limited to fiber and seed — to include the entire plant, specifically the floral parts and cannabinoids derived from it. This put into motion the legal framework for the already burgeoning marketplace for hemp and CBD extracts.
The 2018 Farm Bill also opened up the ability for tribal lands to grow hemp and made provisions for USDA crop insurance and grants.
Can I take your products on an airplane?
As of May 2019, the Transportation Security Administration (TSA) has updated its policy to allow hemp-derived CBD products on domestic flights.
I’m new to CBD. How do I know which product to choose?
All of our products have similar formulations. The main difference is in the strengths. Any of our products will provide you with the beneficial cannabinoids and other phytonutrients needed to support your overall health and wellness. If you are new to Medosi or CBD products in general, we typically suggest starting with our 500mg tincture. It contains 500mg of active cannabinoids which is our lowest strength. It’s a great introductory product intended for general health and wellness.
If you have already tried our products, regularly consume CBD products or have a generally active lifestyle, we recommend starting with our 1000mg tincture. It contains 1000mg of active cannabinoids and comes in a 30ml bottle.
Our strongest formulation can be found in our 3500mg tincture which contains 3500mg of active cannabinoids.
When I squeeze the rubber end of the tincture dropper, the oil does not fill the whole dropper. Am I getting a full dose?
The bottles were designed so the oil does not fill the entire dropper; however when you gently squeeze the rubber end and release, rest assured you are getting a full dose as stated on the packaging.
Are your products cGMP certified?
Yes. All of our finished products are manufactured in a cGMP and ISO certified facility that is registered with the FDA and routinely inspected and audited by the respective certification organizations.
What kind of testing/analysis is performed on your products?
We have a very strict internal quality assurance system, and we also have certified third party laboratories analyze the hemp-CBD oil for THC, cannabidiol potency, heavy metals, bacterial and microbials, mycotoxins (fungal), and pesticides.
Do you provide Certificates of Analysis for your products?
Yes. All of our raw materials and finished products are analyzed by independent third party laboratories, as well as our in-house quality assurance staff. We provide extensive COA reports and post those COAs on our product pages. The COAs can also be found by scanning the QR code on our product packaging.
What extraction methods do you use?
Our main extraction methods are food grade organic ethanol and CO2. Both are very clean methods, but ethanol has the advantage to keep a higher level of the minor cannabinoids, such as CBG, CBN, CBA, etc. On our COAs you'll see that we recover 100% of our ethanol used, so there is no trace in the distillate oil or the final finished products.
We grow our hemp from an organic cloned plant which is then planted in organic soil a few weeks later. This process, rather than just planting seeds in the soil, allows us to keep control of the plant molecule, keeping its THC level low. It also helps in germination that could flow with the wind and compromise our crop.
Other extractors use butane, which is cheaper - but not the most efficient. Cold press and steam press are also other methods used but again - not very efficient.
Will I fail a drug test if I take CBD oil?
This is our most frequently asked question, and it’s a legitimate concern. One survey showed that 57% of all employers require drug tests while a mere 29% said they never used them. That’s the majority of workplaces! And they aren’t the only ones who test, nor are they simply performed as a routine hiring practice. Employers might also issue drug tests at random to enforce compliance in accordance with company policies or require them when someone is injured in the workplace to be compliant with local, state, and federal regulations.
There are lots of additional situations where a drug test might be required - for sports athletes, parole requirements and substance abuse programs. There are a lot of factors at play here, and the simple answer is kind of well – complicated. It’s a solid- yes, no, maybe situation and for a variety of reasons; from compound, to the individual, to dosage, to the test itself.
The short answer is yes, it’s possible to fail a drug test with any CBD product (yes, even isolate CBD.)
Here’s the complicated part. There are a lot of variables at work here, from the drug test itself (different manufacturers, different detection levels, sensitivities) to the individual who consumes the CBD product.
Here are some additional factors to consider:
- Is the product a full spectrum product containing cannabinoids other than CBD?
- How much is consumed and how often?
- Are there existing medical factors, such as medications taken, liver and/or kidney disease?
- And finally, it depends on the metabolism of the individual
Will I fail a drug test if I take full spectrum CBD products?
First, let’s consider full-spectrum products. All of Medosi’s products are derived from hemp, which means they have a naturally low level of THC: less than 3/10 of a percent. This also means they are perfectly permissible under federal law and, thanks to the 2018 Farm Bill, the cannabinoids in these products are permanently removed from the Controlled Substances Act. Due to the low level of THC, these products are not considered intoxicating. They won’t get anyone high.
Although unlikely, it is possible that someone could fail a drug screen when using our products. Drug tests look for elevated levels of the intoxicating molecule, THC. The drug test identifies if a THC level is above a particular threshold; if so, it’s considered positive. Theoretically, you could use enough hemp extract and therefore consume enough THC to truly surpass that threshold and trigger a true positive…but it would be pretty difficult.
And no, there is no “magic dose” of CBD oil or hemp extract that you can take to ensure you stay below the THC threshold in a drug screen. Metabolism of THC is highly individualized and depends on many variables, including body composition, activity level, dose and duration of use.
What’s more likely is that hemp extract will trigger a false-positive. This is because the most commonly used drug tests, urine and saliva immunoassay tests, are so common because they are quick, cheap and easy, but unfortunately, they aren’t very specific. That means they can confuse one molecule for another, especially when they look alike. This can happen with CBD and THC, which would trigger a FALSE positive.
Will I fail a drug test if I take THC-free or isolate products?
We can guarantee that Medosi’s THC free products are 100% THC-free. This is reflected in the Certificate of Analysis, which is completed by an objective, third party-lab and made available on our website, confirming all traces of THC have been eliminated. These THC-free products could be considered “broad spectrum,” as we still include other cannabinoids and terpenes to maximize benefits. We don’t make CBD isolate products, because science supports the benefit of the entourage effect, but the same goes for isolate CBD and drug tests.
STILL, THERE IS POTENTIAL FOR THE CBD IN THC-FREE PRODUCTS TO TRIGGER A FALSE POSITIVE ON AN IMMUNOASSAY URINE DRUG SCREEN. This is possible with any CBD product, even if it is CBD isolate. We have seen companies making guarantees that users will not fail a drug test, and that’s concerning because it’s not the whole truth. You CAN fail a drug test even when the THC is eliminated, because false positives happen with the most common tests. You just can’t get a TRUE positive. But you may need to ask for - and pay for - a confirmation test to demonstrate that true positive.
We know this is frustrating and may not be what you’ve heard elsewhere, but we are committed to honesty and transparency. No one can guarantee false positives won’t occur. We do not want to jeopardize your employment, your livelihood, contract with a pain specialist or commitment to sobriety testing.
Stick to the THC-free line if you absolutely cannot risk failing a drug test. And even then, know that you may need to ask for a confirmation test if the urine or saliva tests shows a false positive. We recommend letting your employer, medical provider or whoever is administering the drug screen know this ahead of time – just in case it becomes an issue. That way, you can assess if they are willing to follow these steps for a confirmation test, if needed. And who knows, maybe they will even cover the cost for the second test. On the other hand, they may say absolutely not – failing an immunoassay test is the end of the road - and then it’s your choice to decide whether or not using hemp-derived CBD products is worth that risk.
How do different cannabinoids affect drug testing?
First, isolated CBD, also known as Cannabidiol, generally will not show up in a drug test. That’s mainly because drug tests are not looking for all cannabinoids; they’re looking for one specific cannabinoid. However, a full spectrum product will contain an array of other cannabinoids (such as CBG, CBN, CBC and THCV) which may show positive on a drug test. Currently we don’t know what other cannabinoids may trigger a drug test.
How long does CBD stay in your system?
The length of time CBD stays in your system depends on many factors, including how much was taken, if there is consistent use, the size and weight of the person and an individual’s metabolism.
What should I do if I fail a drug test?
If you get a positive result on a urine or saliva drug screen, ask for a more specific confirmation test, such as a blood test or a hair test. These are more expensive tests, but they are much more accurate. If using a THC-free product, these will show a true negative 100% of the time. If you are using a full-spectrum product with small amounts of THC, these tests will either show a 100% true negative or a small level of THC. This quantification of THC will help differentiate between use of a hemp product versus use of a marijuana product.
Where does your hemp come from?
We are proud to say that our hemp is grown and processed in the USA. Unlike many of our competitors, we do not use imported CBD extract because it’s not compliant with the Farm Bill. We do not produce any product from the stalk of the hemp plant. All of our extract comes from the flower.
Why do you say you’re not a CBD company?
While other companies talk about CBD, our conversations are grounded in the whole hemp plant – a concept we call whole spectrum health. The whole plant is better than the sum of its parts – and to us, that makes a whole lot of sense. We know that the true value of the plant comes from the whole plant, not just some of its parts.
What does whole spectrum health mean?
We believe in the power of the whole hemp plant, not just parts of it. That’s why our conversations are grounded in a new concept we own called whole spectrum health. Whole spectrum is synonymous with full spectrum, and it is necessary in promoting the entourage effect.
Is your hemp industrial hemp?
We only produce products using hemp that is Industrial Hemp Registered.
Are you compliant with the State Department of Agriculture?
We are fully compliant with the State Department of Agriculture’s regulations and provide some of the most mineral-rich hemp in the United States.
Are you compliant with the Farm Bill?
All of our hemp is USA grown in accordance with Section 7606 of the 2018 US Farm Bill.
How can I be sure of the ingredients in the formulation and quality of the ingredients?
We use the highest quality ingredients when developing each formula. All of our CBD products are made using the highest quality industrial hemp that is manufactured in cGMP certified and FDA registered facilities. We strategically partner with the world’s leading formulators, scientists, doctors and experts to ensure our products are effective, safe and the highest quality in the world. We also provide a Certificate of Analysis with each and every product.
What is a Certificate of Analysis?
CBD is like a box of chocolates. You never know what you’re going to get unless you do a little reading. With CBD oil, it should be as easy as checking the box, but there’s an unfortunate problem of mislabeled products. Protect yourself from fake or low-quality products by doing your due diligence —always check the Certificate of Analysis. If there isn’t one, steer clear.
A Certificate of Analysis, or COA, is a document from an accredited laboratory that shows the quantity of various cannabinoids in a product. A COA is as much for the customer as it is for the company to double-check the quality of their work for quality assurance purposes.
Manufacturers should send every batch of every product they make to a lab for testing, to protect their customers and prove that their products have as much CBD as they advertise.
Do you provide Certificates of Analysis with your products?
Yes, we provide a Certificate of Analysis (COA) with every product. You can find the link to the COA on every product page on our website or by scanning the QR code located on the product packaging.
What are your certifications?
Our manufacturing plants are cGMP certified and registered with the FDA. All of our hemp is organically grown, premium grade, non-GMO, made in the USA, third-party tested, gluten-free, all-natural, industrial hemp registered, Farm Bill compliant, pesticide free, and with no metals and no harsh chemicals.
How is Medosi different from other CBD companies?
We are committed to providing our customers with the highest level of service and quality CBD products available. As an industry leader, we set the standard with premium-grade quality, consistency and transparency in producing effective products. We partner with the world’s leading formulators, scientist, doctors and experts to ensure our products are effective, safe, and the highest quality in the world.
How are your products different from others in the marketplace?
Our exclusive CBD products are created with phytocannabinoid-rich hemp combined with the purest quality ingredients using state-of-the-art technologies to deliver the safest, most consistent and effective products available on the market.
All of our hemp is organically grown, premium grade, non-GMO, made in the USA, third-party tested, gluten-free, all-natural, industrial hemp registered, Farm Bill compliant, pesticide free, and with no metals and no harsh chemicals.
Where are your products grown, and do you source anything out of the country?
Our premium, quality hemp-derived products begin at our 300+ acre farm located in the United States. Grown in the USA, we are Industrial Hemp Registered and compliant with the 2018 Farm Bill. Our products are farmed only in the United States and nothing is imported from any other country.
What is third-party testing, and why is it important?
We start out doing rigorous testing in-house, but we verify our results through independent, third-party labs using HPLC analysis. All batches are tested for highest quality in potency, ensuring consistency and purity of terpenes, essential fatty acids and phyto-nutrients. The entire purpose of third-party or independent lab testing is to provide an unbiased analysis of CBD products.
All About CBD
What is CBD?
Cannabidiol (CBD) is a cannabinoid derived from the hemp plant. It is used for its effective and non-intoxicating pain/stress relieving and anti-inflammatory properties. Not to be confused with THC, CBD does not get you high in any way. This is because CBD does not affect the same receptors as THC. CBD is an entirely different compound from THC, and its effects on the human body are complex.
How does CBD work?
Although it is a cannabinoid, CBD does not directly interact with the two classical cannabinoid receptors (CB1 and CB2). Instead, it affects signaling through the CB1 and CB2 receptors indirectly. These indirect actions include activating TRPV1 receptors that work to control important functions like pain perception, body temperature and inflammation. In addition to its indirect influence on the CB1 and CB2 receptors, CBD can increase levels of the body’s own naturally-produced cannabinoids known as Endogenous Cannabinoids (Endocannabinoids) by inhibiting the enzymes that break them down.
Is CBD legal?
This seemingly simple question used to have many people — from mainstream Americans to federal regulators — utterly confused. Before digging into the details, the bottom line is that cannabidiol is 100% legal across the board thanks to the 2018 Farm Bill signed into law by President Trump. Cannabidiol itself is not specifically listed on the United States Controlled Substances Act, the way THC and marijuana are.
What are the side effects of CBD oil?
There are no known or proven side effects from taking CBD.
What is broad spectrum?
This refers to the full plant extract that contains all of the major cannabinoids and terpenes naturally present EXCEPT those that have THC. All full spectrum phytocannabinoid-rich (PCR) hemp oil must have THC to be considered full spectrum since the plant naturally produces THC.
What do I need to know about dosing?
The amount of CBD that you should take to achieve the best results varies by individual. This fact is strongly supported by feedback from users and the limited clinical research on CBD dosage. Each person’s optimal dosage is based on a variety of factors, including body chemistry, genetics, weight, and physical condition.
The purpose of our CBD dosage guide is to give you tips on where to start and how to go about finding your optimal or “sweet spot” dosage.
What are the 3 basic principles of dosing?
Before you get started, it’s important to understand the 3 basic principles of CBD dosing.
Rule #1: There is no “one-size-fits-all” when it comes to the amount of CBD you should take. Some users get their desired results from as little as 1 milligram of CBD daily, whereas others find that they need over 100 milligrams per day. Finding your personal “sweet spot” dosage will involve some experimentation and adjustments over time.
Rule #2: Getting the dosage right is critically important to achieving success with CBD. Its importance is often overlooked or understated. Many new users don’t take the time to find their optimal dose and just declare that CBD doesn’t work for them. In reality, it may have worked if they had followed the process to find their optimal dose.
Rule #3: It is typically best to start low and gradually increase the dosage over time until you find your optimal dose where you get the desired results. Less is often more when it comes to CBD dosing. Patience is also essential during the process. While some people get results immediately, it’s more common for it to take several days or even weeks.
What is the #1 mistake made by new users?
Taking either too low or too high of a dose is the #1 mistake made by new users. If your dose is too low, you may not feel any effects at all - and if your dose is too high, you may experience undesirable side effects such as headaches, nausea or a general worsening of symptoms.
How do I find my optimal CBD amount?
1. Start Low.
The first step is choosing a starting dose in milligrams of CBD. Our CBD dosage chart is a good place to start.
2. Increase Slowly as Needed.
Take the starting daily dose suggested above for at least one week. It often takes several days for your body to adjust to taking CBD. If you are not getting the desired results after a week, then increase the amount slightly. Keep slowly increasing the dosage every 3-4 days until you get the results that you're looking for. At that point, you've found your optimal dosage level and you can continue taking that amount going forward.
Our CBD dosing journal can be a useful resource to help you track your doses and progress towards finding your optimal dose.
If at any time you experience adverse side effects such as headaches or nausea, it's recommended that you lower the dosage since those are typically signs that you are taking too much.
3. Make Adjustments Over Time.
You can expect that you'll need to do some experimentation and make adjustments to your dosage over time. This includes experimenting with how many times a day and what time of day you take it. It's also common for your optimal dosage level to change.
How many Liquid Gel Caps should I take?
The bioavailability, or amount of CBD that your body absorbs, is lower for capsules than it is for sublingual drops. That’s because the CBD goes through your digestive system when you swallow it. But on the bright side, figuring out the amount of CBD that you’re taking is more straightforward. With capsules, you know exactly how many milligrams you’re taking because the packaging will tell you how many milligrams of CBD are in each capsule.
It’s generally recommended that you start slowly with no more than one capsule. They can take anywhere from 30 minutes to well over an hour to “kick in” since they go through your digestive system. It is recommended that you do not take more than your initial dose until at least 2 hours later given the delayed effect.
What other tips do you have for beginners?
Be sure to shake your bottle of CBD oil well before taking it.
Place the drops under your tongue and hold it there for at least 30-60 seconds. You want the oil to absorb sublingually into your bloodstream for the highest bioavailability, so don’t just swallow it immediately.
Be patient and don’t get discouraged if you don’t get the immediate results that you were hoping for. Many people don’t get measurable results for a couple of weeks. We recommend that you talk to your doctor before starting CBD oil, especially if you are taking prescription medications. Your doctor can make dosage recommendations specifically for you.
Why was hemp legalized?
Following the passage of section 7606 of the 2014 Farm Bill, Kentucky became the first state to create state-sponsored industrial hemp pilot programs. These pilot programs were designed to test the agronomics of the crop and what it could mean to farmers and processors who wanted to enter the industry.
Citing five successful years of growth and an increase of farming salaries, influential policy makers determined that it made sense for hemp to be available for farmers to grow legally in all 50 states. The return of this crop to our nation’s farmers should be heralded as a decree of job creation, economic growth and innovation.